辛伐他汀对急性缺血性卒中患者血清C反应蛋白和尿酸水平的影响

Effect of simvastatin on levels of serum C-reactive protein and uric acid in patients with acute ischemic stroke

目的探讨辛伐他汀对急性缺血性卒中患者血清C反应蛋白(CRP)、尿酸(UA)及血脂水平的影响。方法将69例急性缺血性卒中患者随机分为2组:治疗组予常规治疗+辛伐他汀,对照组仅采用常规治疗。观察2组治疗前后CRP、UA和血脂的变化。结果治疗后,治疗组的CRP、UA、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平显著下降,高密度脂蛋白胆固醇(HDL-C)水平明显升高。结论辛伐他汀在明显降低急性缺血性卒中患者血脂水平的同时,具有抗炎、降UA作用,其降UA作用独立于降脂作用之外。

Objective It is to explore the effect of simvastatin on the levels of serum C- reactive protein （CRP）, uric acid （UA） and blood lipid in patients with acute ischemic stroke. Methods 69 eases of acute ischemic stroke patients were ran- domly divided into 2 groups： the treatment group received conventional therapy and simvastatin, and the control group re- ceived conventional treatment only. The changes of CRP, UA and blood lipid in both groups were observed before and after treatment. Results After treatment, CRP, UA, the levels of total cholesterol （TC）, tow-density lipoprotein cholesterol （LDL- C）, triglycerides （TG） were all decreased, and the high-density lipoprotein cholesterol （HDL- C） levels were sig- nificantly increased in treatment group. Conclusion Simvastatin can significantly reduce acute ischemic stroke patients＇ lipid levels, at the same time, it has anti-inflammatory and reducing-UA effect, but its role in reducing UA is independent of the lipid-lowering.