谷氨酸与卒中后抑郁

Glutamate and Post-Stroke Depression

卒中后抑郁是脑血管病后的常见并发症,严重影响了患者的生活,延长了康复治愈的时间,增加了致残率和致死率,加重了患者和家属的疾病负担。其发病机制尚未完全明了,治疗上主要以抗抑郁的精神药物为主。但是目前常用的抗抑郁药绝大多数以增加5-羟色胺和去甲肾上腺素的突触利用率为目标。这些抗抑郁药的效果不超过60%～65%,并需要2～4周才能发挥其疗效,近年的研究发现"谷氨酸及其受体"也参与抑郁症的发病机制。本文就卒中后抑郁与谷氨酸及其受体的关系方面的研究进行综述。

Post-stroke depression （PSD） is one of the most common complications after cerebral vascular disease, which can have a severe influence on the life of the patients, prolongs the rehabilitation time, increases the rate of disability and fatality, and increases the load of both patients and their relatives. Its pathogenesis isn＇t known completely. The main treatment of PSD is antidepressive drug. Drugs increasing the synaptic availability of serotonin and norepinephrine have been used to treat depression for many years in clinical. However, significant symptom improvement requires 2-4 weeks of treatment and a first course of therapy provides symptom relief to only 60%-65% of patients. The increasing understanding of the molecular mechanisms of depression shows that glutamate and its receptors are also involved in depression .Here we describes the relationship of glutamate and its receptors between PSD.