慢性乙型肝炎中医证型与生化及氧化损伤指标的相关性研究

Correlative Study on TCM Syndrome of Chronic Hepatitis B and Indexes of Serum Biochemistry and Oxidative Stress

目的:探讨慢乙肝患者生化、氧化损伤指标与中医证型的相关性。方法:对381例慢乙肝患者进行辨证分型,以同期健康体检正常者30例为正常对照组,检测血清生化及脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)。结果:①AST、ALT、GGT、NO、MDA在湿热中阻、瘀血阻络、肝肾阴虚证中较其它证型显著升高(P<0.01或P<0.05);②GLO、LPO、aPOA-1/aPOB在瘀血阻络、肝肾阴虚证中高于其它证型而ALB、A/G比值较低(P<0.01);③TBA、CHE、aPOA-1、aPOB在瘀血阻络、肝肾阴虚、脾肾阳虚证中明显低(P<0.01)。结论:生化及氧化损伤指标可为慢乙肝中医辨证的客观化提供依据。

Objective：To explore the correlation between different syndrome types of TCM and indexes of serum biochemistry and oxidative stress in chronic hepatitis B（CHB）.Methods：381 patients of CHB were classified as well as diagnosed with blood serum biochemistry、LPO、SOD、MDA、NO,and compared with 30 cases health control group.Results：①Comparision among the different syndrome types revealed that AST、ALT、GGT、NO、MDA were significantly raised in damp-heat obstracting the center,static blood obstructing the network vessels and liver-kidney yin deficiency（P0.01orP0.05）;②GLO、LPO、aPOA-I/aPOB were markedly elevated and meanwhile ALB、A/G activity decreased in static blood obstructing the network vessels and liver-kidney yin deficiency（P0.01）;③Comparision among the different syndrome types revealed that TBA、CHE、aPOA-I、aPOB were markedly decreased in static blood obstructing the network vessels,liver-kidney yin deficiency and spleen-kidney yang deficiency（P0.01）.Conclusions：blood serum biochemistry and oxidative stress could serve as objective indexe for syndrome typing of CHB.