摘要
目的:观察川芎、鸡血藤、苏木、水蛭4种活血药对C57BL/6小鼠移植性Lewis肺癌不同阶段的移植瘤和肺转移的影响。方法:建立C57BL/6小鼠移植性Lewis肺癌肺转移模型,分别给予川芎、鸡血藤、苏木、水蛭单药灌胃,分3个时间点与模型对照组进行比较,动态观察各组抑瘤率和转移情况。结果:第5天,鸡血藤组和苏木组的瘤重与对照组相比差异有统计学意义(P<0.05),第10天,鸡血藤组、苏木组和水蛭组的瘤重与对照组相比差异有统计学意义(P<0.05),第21天,用药各组瘤重与对照组相比差异无统计学意义(P>0.05)。川芎组、苏木组肺转移灶数目与对照组相比差异有统计学意义(P<0.05)。结论:根据本实验4种活血药均有一定的抑瘤及抑制转移作用,但随着病期的进展作用逐渐减弱。
Objective:To observe the effects of four kinds of hemorheologic agents,on tumor growth,metastasis of mice transplanted with Lewis lung carcinoma.Methods:Hemorheologic agents were orally administered to C57BL/6 mice transplanted with Lewis lung carcinoma cells respectively.The transplanted tumor weight and lung metastatic foci of the mice were evaluated and compared with those of untreated mice in three phases.Conclusion:Four kinds of hemorheologic agents can inhibit the tumor growth and metastasis.The effection was weaker and weaker during the disease developed.
出处
《辽宁中医杂志》
CAS
北大核心
2010年第3期546-548,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(30873334)
关键词
LEWIS肺癌
自发性肺转移
活血药
Lewis Lung cancer
spontaneous pulmonary metastasis
hemorheologic agent