摘要
报道了以水为溶剂,硼酸为催化剂,室温下通过三组分Strecker反应合成α-氨基腈类化合物的方法,考察了不同溶剂及催化剂对反应的影响。与经典的Streaker反应相比,它具有产率高、反应时间短和环境友好等优点。目标化合物的结构经1HNMR、IR确证。
A method for the three-component Strecker reaction with water as solvent, boric acid as catalyst at room temperature is reported. The effects of different solvents and catalyst on the reaction were studied. Compared to the classical Streaker reaction conditions, the present method has the advantages of good yields, short reaction time and environmentally friendly. The structures of the products were characterized by ^1H NMR and IR spectra.
出处
《化学通报》
CAS
CSCD
北大核心
2010年第2期184-187,共4页
Chemistry
基金
国家自然科学基金项目(20472067)
陕西省教育厅专项基金项目(09JK734)资助
关键词
α氨基腈
硼酸一锅法
水相反应
α-Aminonitriles, Boric acid, One-pot synthesis, Reaction in water
