可溶性CD14和HCMV感染与冠心病病情变化关系

THE RELATIONSHIP AMONG SOLUBLE CD14 AND HUMAN CYTOMEGALOVIRUS INFECTION AND PATHOGENIC CONDITION IN CORONARY HEART DISEASE

目的探讨可溶性CD14（sCD14）和人巨细胞病毒（HCMV）感染与冠心病（CHD）病情变化的关系。方法应用ELISA法测定120例CHD病人血清sCD14和HCMV—IgG的浓度，其中急性心肌梗死（AMI）、不稳定型心绞痛（UAP）和稳定型心绞痛（SAP）病人各40例，并与40例健康体检者（对照组）进行比较。结果AMI、UAP与SAP组SCD14和HCMV—IgG的浓度均显著高于对照组，差异有显著意义（F=132．94、49．07，q=9．70～27．58，P〈0．01）。AMI、UAP与SAP病人sCD14和HCMV-IgG比较，差异有显著性，且以AMI病人增高最明显（q=2．92～17．88，P〈0．05、0．01）。结论血清sCD14浓度升高和HCMV感染程度可能与冠状动脉病变程度有关，对冠状动脉病变程度有预测价值。

Objective To explore the relationship among serum soluble CD14 （sCD14） level and human cytomegalovirus （HCMV） infection and progression of coronary heart disease （CHD）. Methods The serum sCD14 and HCMV-IgG were determined in 120 patients with CHD by enzyme linked immunosorhent assay （ELISA）, in which, the number of patients with acute myocardial infarction （AMI）, stable angina pectoris （SAP）, and unstable angina pectoris （UAP） were 40, respectively. The results were compared with 40 healthy subjects who served as controls. Results The levels of sCD14 and HCMV-IgG in the AMI, UAP, and SAP patients were higher than that of the control （F=132.94,49.07;q=9.70-27.58,P〈0.01）. The differences between the levels of sCD14 and HCMV IgG among the patients with AMI, UAP and SAP were significant, expeeially in the AMI （q=2.92 17.88;P〈0.05,0.01）. Conclusion The rising of sCD14 and the extent of HCMV infection are probably associated with pathological changes of CHD, which is of a value in the prediction of the disease.