摘要
目的研究人着色性干皮病G组（XPG）基因C46T与以奥沙利铂为主：的化疗方案对晚期胃癌疗效的相关性。方法用REAL—TIMEPCR技术检测92例晚期胃癌病人外周静脉血DNA的XPG基因的单核苷酸多态性（SNP）分型。比较3种基因型与病人的2周期化疗临床疗效的关系。结果92例病人的C／C、T／T、C／T基因型分别占51．09％、38．04％、10．87％。C／C与T／T＋C／T基因型化疗有效率分别为76．59％、53．33％，两组比较差异有显著意义（χ^2=5．484，P〈O．05，OR=2．942，95％CI=1．195～7．248）。结论XPG基因多态性与奥沙利铂疗效之间存在相关性，其检测结果可以作为胃癌选择奥沙利铂化疗的参考。
Objective To research the correlation between XPG gene polymorphism and therapeutic effect of oxaliplatin for a,dvanced gastric cancer （AGC）. Methods Real-time PCR was used to detect XPG single nucleotide polymorphlsm of peri- pheral venous blood DNA of 92 AG C patients. The relationship between the genotype and the clinical response after two cycles of chemotherapy was compared. Results The genotypes of C/C, C/T and T/Tof the92 patients were 51. 09% （47/92）, 38, 04% （35/9.2） and 10.87% （10/92）, respectivcly. The effective rates of chemotherapy in C/C genotype and T/T ＋ C/T genotypes were 76.59 % and 53.33 %, respectively, the differences was significant （χ^2 = 5. 484 P〈0.05, OR=2. 942,95% CI= 1. 195--7. 248）. Conclusion There was a correlation between XPG gene polymorphism and efficacy of oxaliplatin. The results of XPG genotyping can be used as a reference for selecting oxaliplatin chemotherapy for gastric cancer.
出处
《齐鲁医学杂志》
2010年第2期98-100,共3页
Medical Journal of Qilu
关键词
胃肿瘤
XPG基因
多态性
单核苷酸
奥沙利铂
stomach ncoplasms
XPG gene
polymorphism, single nucleotide
oxaliplatin
