红花黄色素对老年高血压患者左心室舒张功能的影响

Influence of safflower yellow on left ventricular diastolic function in geriatric patients with hypertension

目的研究红花黄色素对老年高血压患者左心舒张功能不全的影响。方法选取156例高血压病伴舒张功能不全的老年患者随机分为地尔硫组(52例)、红花黄色素组(52例)和对照组(52例),对照组仅采用常规抗高血压治疗,其余2组在常规抗高血压治疗基础上分别给予地尔硫和红花黄色素,均治疗4周,用组织多普勒成像技术(TDI)测量二尖瓣前后叶瓣环运动的收缩期运动速度(Sm)、舒张早期运动速度(Em)、舒张晚期运动速度(Am),用Em/Am评价左心室舒张功能。结果与对照组比较,地尔硫组和红花黄色素组Em、Em/Am均显著升高(P<0.05或0.01),而且红花黄色素组Am也显著降低(P<0.05),但这2组的疗效并无显著性差异(P>0.05)。结论红花黄色素能够显著改善老年高血压患者的左心室舒张功能。

Objective It is to study the influence of safflower yellow on diastolic dysfunction in geriatric patients with hypertension. Methods 156 patients were chosen and randomly divided into Diltiazem group, safflower yellow group and control group in which there was 52 cases respectively. The control group were treated with common antihypertensive agent, based on it the other two groups administered Diltiazem and safflower yellow respectively. After 4 weeks of treatment, the mitral annulus motion velocity of systole （Sm）, early and late diastolic phase （Em, Am） and Em/Am was measured by tissue Doppler imaging （TDI）, which were used to assess the left ventricular diastolic function. Results Compared with control group, the Era, Em/Am in Diltiazem group and safflower yellow group were significantly heightened （P 〈 0.05 or 0.01 ）, and the Am in safflower yellow group were significantly decreased （ P 〈 0.05 ）. There was no significant difference on the curative effect between the two groups （P 〉0.05）. Conclusion Safflower yellow can significantly improve the left ventricular diastolic dysfunction in geriatric patients with hypertension.