苦参碱联合阿德福韦酯治疗慢性乙型肝炎30例

Matrine combined with Adefovir dipivoxil in the treatment of 30 cases of chronic hepatitis B

目的探讨抑制乙肝病毒(HBV)复制,治疗慢性乙型肝炎(CHB)安全有效的新方法。方法采取随机分组,2组对比。抽取空腹血化验肝功能、乙肝病毒标志物及乙肝病毒复制指标,2组比较采用t检验,计数资料采用χ2检验。结果治疗组患者丙氨酸转氨酶(ALT)复常率、乙肝病毒血清学指标HBeAg阴转率明显高于对照组(P<0.05),但2组乙肝病毒核酸指标HBV-DNA转阴率和HBeAg/抗-HBe血清转换率无显著性差异(P>0.05)。结论阿德福韦酯联合苦参碱治疗CHB可促进患者肝功能改善,增强抗HBV作用,二者联用有一定协同作用,是治疗CHB的一种安全有效的方法。

Objective To explore the inhibition of hepatitis B virus replication and the safe , effective new approach treatment of chronic hepatitis B （ CHB ） . Methods Random group and contradistinction was adopt. Fasting blood samples for testing liver function, hepatitis B virus markers and hepatitis B virus replication loads were tested . Group comparison with t- test and numeration dat with chi square test.Results ALT normalization and HBeAg negative rate in the treatment group were obviously higher than in the control group （P〈0.05）, but there was no significant difference （P〉0.05）in the HBV DNA negative and HBeAg/anti-HBe seroconversion rate in two groups. Conclusion Matrine combined with Adefovir dipivoxil in treatment of CHB can improve liver function and enhance the effect of anti-HBV, and it is a safe and effective method for treatment of chronic hepatitis B.