摘要
目的观察安理申联合丁苯肽对血管性认知功能障碍患者的治疗作用。方法把入选的患者随机分为安理申与丁苯肽联合治疗组30例,安理申治疗组30例,对照组28例。对照组不使用改善认知的药物。3组患者分别在治疗前进行MoCA量表的测评,治疗后2和4个月分别随访患者,再次进行MoCA量表的测评。结果安理申和丁苯肽联合治疗组与安理申治疗组认知功能改善比较差异有统计学意义(P<0.05),安理申和丁苯肽联合治疗组与安理申治疗组MoCA主要各子项目比较差异有统计学意义(P<0.05)。结论安理申和丁苯肽联合治疗对VCI患者的认知功能有较好的改善作用,且两者联合治疗对MoCA评分主要子项目都有较好的改善作用。
Objective To investigate the effect of combination of donepezil and butylphthalide in treating vascular cognitive impairment on cognitive function. Methods Eighty-eight patients with vascular cognitive impairment were randomly divided into 3 groups： the group treated with donepezil, the group treated with donepezil and butylphthalide, the control group treated without any medcine or herb to improve vascular cognitive impairment. MoCA Scale of three groups was assessed and compared before treatment and 2 months, 4 months after treatment. Results The cognitive function was improved markedly in the group treated with donepezil and butylphthatide （P〈0.05）, so did in main item of MoCA. Conclusion Combination of donepezil and butylphthalide can markedly ameliorate the cognitive function and main item of MoCA in patients with vascular cognitive impairment.
出处
《中国实用神经疾病杂志》
2010年第5期9-11,共3页
Chinese Journal of Practical Nervous Diseases
