白细胞计数和纤维蛋白原及相关危险因素与冠状动脉病变程度分析

Correlative analysis of the extent of coronary lesion with leukocytes count,fibrinogen and some related risk factors

目的:探讨纤维蛋白原和白细胞计数与冠状动脉病变程度的关系及是否是冠心病的独立危险因素。方法:入选行冠状动脉造影的住院病例387例,其中造影确诊冠心病患者284例。冠状动脉病变程度由造影所示的病变支数表示。心血管危险因素:年龄、性别、高血压、糖尿病、高纤维蛋白原(FIB)血症、外周血白细胞(WBC)计数;高低密度脂蛋白胆固醇(LDL-c)血症、低高密度脂蛋白(HDL-c)血症。采用单因素方差分析和多因素回归分析方法筛选危险因素。结果:(1)单因素方差分析显示,随着危险因素指标的增加,冠状动脉病变的程度加重。(2)多因素Logistic回归分析显示,年龄、性别、糖尿病、WBC计数、高LDL-c、低HDL-c是冠心病的独立危险因素(均P<0.05)。FIB在冠心病与非冠心病组之间有显著性差异,但不是冠心病的独立危险因素(P=0.093)。高血压亦不是冠心病的危险因素(P=0.936)。结论:高龄、男性、糖尿病、高LDL-c、低HDL-c、WBC计数是冠心病的独立危险因素,FIB、高血压不是冠心病的独立危险因素。

Objective： To evaluate the relationship between the extent of coronary lesion and the plasma fibrinogen ,leukocytes levels and some related risk factors. Methods： Three hundred and eighty seven patients whom undergone coronary angiography were chose, among them, two hundred and eighty four were diagnosed coronary arteries disease （CAD） ,the rest patients were normal just as controls. The extent of lesion of coronary arteries was exhibited by the numbers of mainly stenosed coronary arteries. In this study, the risk factors were： age, gender, hypertension, diabetes mellitus, white blood cell count, hyperfibrinogenemia, hyperlipidemia. The univariate and multivariate analysis were used as the statistical methods. Results： （1）Being tested by univariate analysis ,we found that the extents of coronary lesions were increased as the risk factors numbers accumulation. （2） Multi-Logistic regression analysis showed that age, gender, diabetes mellitus, white blood cell count, hyperlipidemia were the independent risk factors for CAD （P〈0.05） but not that fibrinogen and hypertension （ FIB： P = 0.093, HBP：P = 0.936 ）. Conclusion： Older, male, diabetes mellitus, white blood cell count, hyperlipidemia are self sustaining risk factors of CAD. Hyperfibrinogenemia and hypertension are not independent risk agents.