急性低频感音神经性听力损失的发病机制探讨

The analysis of-SP and AP in patients with acute low—frequency sensorineural hearing loss

目的:探讨急性低频感音神经性听力损失(ALHL)的发病机制。方法:对41例ALHL患者进行耳蜗电图检测,并测量-SP、AP的幅值,AP潜伏期及-SP/AP比值。结果:41例ALHL患者-SP幅值分别为:患耳(0.55±0.46)μV,健耳(0.29±0.21)μV,差异有统计学意义(P<0.01);AP幅值分别为:患耳(1.31±0.84)μV,健耳(1.29±0.73)μV,差异无统计学意义(P>0.05);AP潜伏期分别为:患耳(1.73±0.20)ms,健耳(1.71±0.28)ms,差异无统计学意义(P>0.05)。-SP/AP比值分别为:患耳0.42±0.18,健耳0.24±0.11,两组比较差异有统计学意义(P<0.01)。患耳(41耳)中有24耳(58.54%)-SP幅值异常增高,27耳(65.85%)-SP/AP比值异常增高。健耳(41耳)中有9耳(21.95%)-SP幅值异常增高,3耳(7.32%)-SP/AP比值异常增高。结论:急性低频听力损失患者患耳较多出现-SP幅值和-SP/AP比值异常增高,提示急性低频听力损失可能与内淋巴积水有关。

Objective： To approach the pathogenesis of acute low--frequency sensorineural hearing loss. Methods： Electrocochleogram（ECochG） was recorded and the -SP and AP amplitude and AP latency and -SP/AP was measured. Results： There was no difference between the ill ears and the healthy ears in both AP amplitude（P〉0.05） and AP latency（P〉0.05） while both - SP amplitude（P〈0.01） and -SP/AP （P〈0.01） were significantly different. In the ill ears,there were -SP amplitude abnormal increasing in 24 ears （58.54%）,-SP/AP ratio abnormal increasing in 27 ears （65.85%）. In the healthy ears ,there are -SP amplitude abnormal increasing in 9 ears （21.95%）,-SP/AP ratio abnormal increasing in 3 ears （7.32%）. Conclusion： More than half of patients with acute low--frequency sensorineural hearing loss show elevated -SP/AP, which implys the possible relationship between acute low--frequency sensofineurat hearing loss and endolymphatic hydrops.