2245例不孕不育患者抗精子抗体与解脲支原体结果分析

Analysis on the Antisperm Antibody and Ureaplasma Urealytieum for 2245 patients with infertility

目的 探讨抗精子抗体（AsAb）与不孕不育的关系，并分析解脲支原体（Ureaplasma Urealyticum，uu）感染与血清AsAb的关系。方法分别应用分离培养法与酶联免疫吸附试验fELISA法）对2245例不孕不育患者进行AsAb和UU检测，同时与健康组作对比研究。结果不孕不育患者血清AsAb阳性率为24．94％，正常对照组阳性率为3．85％，两组相比差异具有显著性（P〈0．05）；女性不育组血清AsAb阳性率为27．78％，男性不育组阳性率为13．13％，两组相比差异具有显著性（P〈0．05）；UU感染组血清AsAb阳性率为47．06％，UU未感染组血清AsAb阳性率为13．80％，两组相比差异具有显著性（P〈0．05）；作Pearson相关分析显示不孕不育患者UU感染与血清AsAb呈正相关（r=0．355，P=-0．022）。结论AsAb与不孕不育密切相关，UU感染可增加AsAb的产生，对不育夫妇进行病因初筛时有必要检测抗精子抗体和解脲支原体。

To investigate the relationship between serum antisperm antibody （AsAb） and infertility, and study the relationship between Ureaplasma Urealyticum （UU） and AsAb.Methods The serum AsAb of 2245 infertility patients were determined by using enzyme linked immunosorbent assay （ELISA） and compared to the normal control. Microbiological culture method was used to detect the UU. Results The AsAb positive rate of infertility group was 24.94 %, significantly higher than 3.85% in the control group（P〈0.05）; The AsAb positive rate of female infertility group was 27.78 %, obviously higher than 13.13% of the male infertility group （P〈0.05） .The positive rate of AsAb were 47.06% in infectivity group of UU, 4.70% in uninfectivity group of UU respectively. There was all significant difference between the two groups（P〈0.05）. The infection of UU was positively correlated with AsAb for Pearson correlation test （ r=0.355, P=0.022）.Conclusion Antisperm antibody was closely related to infertility, The UU may be increase the production of AsAb.