内-α-取代-α-甲基双环[2,2,1]庚烷-2-基甲醇的合成及其结构与香气的关系

Syntheses of Some Endo-o-Substituted-o-methyl Bicyclo[2,2,1]heptane-2-methanols and Relations Between Their Structures and Odors

合成了18种内-α-取代-α-甲基双环[2,2,1]庚烷-2-基甲醇(Ⅰ)。测定了所有化合物的折光率(或熔点)、质谱、红外光谱、~1H核磁共振谱、气相色谱的保留时间和薄层色谱的比移值。评定了它们的香气,并与相应的内-α-取代-α-甲基双环[2,2,1]-5-庚烯-2-基甲醇(Ⅱ)系列化合物的香气进行了比较,初步探讨了结构与香气的关系。

Eighteen title compounds were synthesized. The refractive indices (or melting points), retention times in GLC, Rf in TLC, MS, IR and 1H NMR spectra of these compounds were obtained. Their olfactory characteristics were evaluated and compared with endo-a-substituted-a-methylbicyclo[2, 2, 1]hept-5-ene-2-methanols. The relations between structures and odors were discussed.