摘要
制备了六批兔A型产气荚膜梭菌类毒素疫苗和其全菌灭活疫苗,并且对其安全性和免疫效力进行了比较研究。结果表明,类毒素灭活疫苗无毒副作用,局部刺激小,安全性好于全菌灭活疫苗。免疫效力结果二者无明显差异,两种疫苗的攻毒保护率均不低于4/5,免疫期均在6个月以上。
Six batches of toxoid vaccine and inactivated whole-cell vaccine were prepared using Clostridium perfringens type A.And we had compared the safety and immune efficacy with the toxoid vaccine and inactivated whole-cell vaccine.The results showed that the toxoid vaccine is safe and non-toxic,better than the inactivated whole-cell vaccine.The difference of efficacy was not significant.The protection rate of two vaccines were more than 80%,the protection period of two vaccines were more than six months.
出处
《中国兽药杂志》
2010年第2期15-16,共2页
Chinese Journal of Veterinary Drug
关键词
A型产气荚膜梭菌
灭活疫苗
安全性
免疫效力
Clostridium perfringens type A
inactivated vaccine
safety
immune efficacy