曲美他嗪治疗不稳定型心绞痛的疗效观察及其对C-反应蛋白的影响

To Observe the Curative Effect of Trimetazidine on the Patients with Unstable Angina Pectoris and the Influence of Trimetazidine on C-reactive Protein

目的评价曲美他嗪治疗不稳定型心绞痛的疗效及其对C-反应蛋白(CRP)的影响。方法我院43例符合标准的不稳定型心绞痛患者随机分为对照组(22例)和治疗组(21例)。对照组患者给予基础治疗(硝酸酯类,β-受体阻滞剂,抗凝剂及阿司匹林等),治疗组在此基础上加用曲美他嗪,疗程均为4周。治疗前、后进行心电图检查,记录心绞痛发作次数及每次心绞痛发作的时间,同时检测治疗前后血清C-反应蛋白含量。结果两组患者临床疗效差异有统计学意义(P<0.05)。两组患者治疗后心绞痛发作次数、持续时间、C-反应蛋白含量差异均有统计学意义(P<0.05)。结论曲美他嗪可明显改善不稳定型心绞痛患者临床疗效,显著降低不稳定型心绞痛患者血清CRP水平。

Objective To evaluate the curative effect of trimetazidine on the patients with unstable angina pectoris and the influence of trimetazidine on c - reactive protein（CRP）. Methods 43 patients with unstable angina pectoris were divided into two groups by randomly： the controlled group （n = 22 ）and the test group （n = 21 ）. In the controlled group, patients accepted the treatment with nitrate,β--blocker and aspirin, in the test group, trimetazidine were given in addition to conventional therapy. The treatment durations in both groups were 4 weeks. Evaluate the clinical effect and change of the electrocardiogram and the frequency and the lasting time of angina ; at the same time, to detect the change of c - reactive protein level in serum of the patients with unstable angina pectoris. Results Two groups of patients with clinical efficacy difference was statistically significant （ P 〈 0.05 ）. Two groups of patients after treatment, the attack of angina frequency, duration difference was also statistically significant（P 〈 0.05 ）. Conclusion Trimetazidine can obviously improve the clinical curative effect on the patients with unstable angina pectoris by notable depressing the level of CRP.