早期应用苯巴比妥治疗新生儿缺氧缺血性脑病的临床研究

Clinical study on the early usage of Phenobarbital in neonatal hypoxic-ischemic encephalopathy

目的:探讨早期应用苯巴比妥对新生儿缺氧缺血性脑病(HIE)治疗的影响。方法:将100例HIE新生儿随机分成治疗组(50例)和对照组(50例),治疗组生后即给予苯巴比妥静脉治疗5d,观察其惊厥、黄疸发生情况,并行精神运动发育商(DQ)评估和伤残率比较,判断疗效。结果:治疗组惊厥、黄疸、DQ评估和伤残率均明显优于对照组(均P<0.05)。结论:HIE患儿早期应用苯巴比妥疗效满意,值得推广。

Objective： To investigate the influence of early usage of Phenobarbital in neonatal hypoxie-ischemie en- cephalopathy. Methods： 100 patients were randomly divided into treatment group and control group, with 50 patients in each group. Phenobarbital was given for five days in treatment group. The condition of eclampsia, choloplania, development quotient （DQ） and deformity rate were recorded and compared between the two groups. Results： The condition of eclampsia, choloplania, DQ and deformity rate of treatment group was better than those of control group （P〈0.05）. Conclusion： Early usage of Phenobarbital is very effective to treat neonatal hypoxic-ischemic encephalopathy.