1Christian W,Antonio T,Clifton B,et al.Insulin resistance and insulin secretary dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development.Diabetes Care,2001,24( 1 ):89-94.
2Amoah A G,Owusu S K,Schuster D P,et al.Pathogenic mechanism of type 2 diabetes in Chanaians-the importance of beta cell secretion,insulin sensitivity and glucose effective-ness.Afr Med,2002,92 ( 5 ):377-384.
3Harmon JS,Gleason CE,Tanaka Y,et al.In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression.Diabetes,1999,48 (10):1995.
4Shimabukuro M,Zhou YT,Levi M,et al.Fatty acid-induced βcell apoptosis:a link between obesity and diabetes.Proc Natl Acad Sci USA,1998,95(5 ):2498-2502.
1Dixon JB.The effect of obeity on health outcomes.Mol Cell Endocrinol,2010,316:104-108.
2Bonnet F,Deprele C,Sassolas A,et al.Excessive body weight as a new independent risk factor for clinical and pathological progression in primary Ig A nephritis.Am J Kidney Dis,2001,37:720-727.
3Tozawa M,Iseki K,Iseki C,et al.Influence of smoking and obesity on the development of proteinuria.Kidney Int,2002,62:956-962.
4Fox CS,Larson MG,Leip EP,et al.Predictors of newonset kidney disease in a communitybased population.JAMA,2004,291:844-850.
5Yoo TW,Sung KC,Shin HS,et al.Relationship between serum acid concentration and insulin resistance and metabolic.Circ J,2005,69:928-933.