药物加间歇拔伸手法治疗缺血性脑血管病合颈椎间盘突出症30例

Clinical Observation on Drugs plus Intermittence Pulling Manipulation in Treating 30 Cases of Ischemic Cerebrovascular Disease Combined with Cervical Disc Herniation

目的观察药物加间歇拔伸手法对缺血性脑血管病合颈椎间盘突出症的疗效。方法比较治疗组和对照组治疗前后神经功能缺损程度评分值、纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制剂-1(PAI-1)的含量。结果治疗组t-PA含量明显降低,PAI-1含量明显增高,t-PA/PAI-1明显降低,神经功能缺损评分值降低;治疗前后神经功能缺损评分值与t-PA、t-PA/PAI-1呈负相关,与PAI-1呈正相关。结论药物加间歇拔伸手法可改善缺血性脑血管病合颈椎间盘突出症患者的神经功能,促进血管内皮细胞的修复,缓解血管痉挛,促进侧支循环。

Objective To observe the curative effect of drugs plus intermittence pulling manipulation on ischemic cerebrovascular disease combined with cervical disc herniation patients. Methods Patients were randomly divided into two groups, the treatment group were received drugs plus intermittence pulling manipulation, and the control group received pure drugs only. The neurologic impairment level score, levels of tissue plasminogen activator （t-PA） and plasminogen activator inhibitor-1 （PAI-1） in two groups before and after the treatment were compared. Results The level of PAI-1 of patients in the treatment group was increased obviously after treatment, while the levels of t-PA, t-PA/PAI-1, and the neurologic impairment level score were decreased obviously. The neurologic impairment level scores of patients before and after the treatment were showed negative correlations with t-PA and t-PA/PAI-1, while positive negative with PAI-1. Conclusion Drugs plus intermittence pulling manipulation can improve clinical nerve function, promote repair of vascular endothelial cells, alleviate vasospasm and improve collateral circulation.