摘要
将水溶性手性二胺(S,S)-1,2-二苯基乙二胺二磺酸钠((S,S)-DPENDS)与钌膦配合物([RuCl2(TPPTS)2]2)原位生成的催化剂用于催化水相中苄叉丙酮的不对称加氢反应.在优化条件下,羰基加氢产物4-苯基-3-丁烯-2-醇的选择性可达96.0%,对映选择性可达71.2%.经正己烷简单萃取后即可实现催化剂与加氢产物的分离,循环使用5次后,目标产物4-苯基-3-丁烯-2-醇选择性和对映选择性没有明显下降.
The asymmetric hydrogenation of benzalacetone catalyzed by ruthenium monophosphine complex RuCl2（TPPTS）2 [TPPTS = P（m-C6H4SO3Na）3] modified by （S,S）-DPENDS （disodium salt of sulfonated （S,S）-1,2-diphenyl-1,2-ethylene-diamine） was investigated in a water medium. Under the optimized conditions, a chemoselectivity of 96.0% for 4-phenyl-3-butene-2-ol and ee value of 71.2% were ob-tained. The products could be easily obtained by simple extraction with n-hexane, and the catalyst could be reused five times without evident loss of catalytic activity and enantioselectivity.
出处
《催化学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第3期273-277,共5页
基金
国家自然科学基金(20272037)
教育部"春晖计划"(Z2007-1-63016)
重庆市教委基金(KJ081402)
关键词
钌膦配合物
苄叉丙酮
水相
不对称加氢
对映选择性
ruthenium monophosphine complex
benzalacetone
water medium
asymmetric hydrogenation
enantioselectivity
