血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction

探讨汉族人群血管紧张素原(AGT)基因CD235Met-Thr变异与高血压合并脑梗塞发生的关系.采用突变基因分离聚合酶链反应(MS-PCR)方法检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的M235T等位基因型.BI组AGT基因T/T基因型频率和T等位基因频率(分别为0.720和0.811)显著高于C组(分别为0.516和0.700,P<0.05)和EH组(分别为0.537和0.716,P<0.05).结果提示,AGT基因CD235Met-Thr变异增加了汉族人群高血压合并脑梗塞发病的易感性.

The angiotensinogen （AGT） gene polymorphism was detected in the study of 82 cerebral infraction （BI） cases,67 simple essential hypertension （EH） cases,and 95 normal cases （control） using mutagenically separated PCR （MS-PCR） technique. The association of the AGT gene CD235Met-Thr variant and cerebral infraction （BI） in Chinese hypertension disease is evaluated. The frequencies of T/T genotype and T allele （0.720 and 0.811） in the BI group were significantly higher than those in the control group （0.516 and 0.700,P〈0.05） and the EH group （0.537 and 0.716,P〈0.05）,respectively. These results suggest that the AGT gene CD235Met-Thr variant is significantly associated with Chinese hypertensive patients with cerebral infraction.