两种免疫抑制剂对肾移植受者外周血象及红细胞生成素的影响

Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients

目的探讨两种免疫抑制治疗方案对肾移植受者外周血象及红细胞生成素(EPO)的影响。方法按免疫抑制方案的不同,将肾移植受者分为雷帕霉素(RAP)方案组(28例)和他克莫司(FK506)方案组(44例)。在两组肾移植受者随访时采集外周血,检测血常规指标、网织红细胞指标、血清EPO和血清肌酐(Cr)。比较并分析两方案肾移植受者各项指标间的差异。结果RAP方案组外周白细胞、红细胞、血小板数和血红蛋白含量较FK506方案组显著降低(P<0.01),EPO则明显升高(P<0.01)。两组间网织红细胞和血清Cr无显著性差异(P>0.05)。结论以RAP为主的免疫抑制治疗方案对肾移植受者的骨髓抑制明显,外周血象影响较大,EPO出现代偿性升高。

Objective To investigate the effect on peripheral blood parameters and erythropoietin （EPO） of renal transplantation patients with different treatment of new immunosuppressive agents. Methods According to different immunosuppressive regimens, recipients were divided into rapamycin （RAP） group （28 cases） and taerolimus （FKS06） group （44 cases）. During follow-up of the recipients, peripheral blood parameters, reticulocyte parameters, serum EPO level and serum creatinine were measured and analyzed. Results RBC, WBC, PLT and HGB of RAP group were significantly lower than that of FK506 group （ P 〈 0.01 ）. RAP group has higher level of EPO concentration（ P 〈 0.01 ）, but RET and Cr are no significant different from FK506 group（ P 〉 0.05 ）. Conclusion RAP based immunosuppressiou regimen has bone marrow depressive effect and obviously influences the peripheral blood parameters. High level EPO was compensatory response.