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白细胞介素6受体基因多态性与肥胖的关联研究 被引量：3

Association of interleukin-6 receptor genepolymorphism with obesity
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摘要 探讨白细胞介素6受体（IL-6R）基因多态性与肥胖间的相关性，观察到IL-6R基因多态性与体重指数、腰围明显相关，Asp／Asp纯合子发生肥胖的危险性较Ala／／Ala纯合子更高（OR=1．32，95％CI1．07～1．68，P=0．041）。提示白细胞介素6受体基因变异在肥胖的发病中具有一定的作用。 To examine the relationship between genetic variants in the interleukin-6 receptor gene and obesity. The result showed that the carriers of Asp358 homozygotes had higher risk in developing obesity when compared with Ala358 homozygotes （ OR = 1.32,95% CI 1.07-1.68, P = 0. 041 ）. Interleukin-6 receptor gene polymorphism was significantly associated with obesity.
作者 闫彩凤 向红丁 陈伟 平凡 杨敏
机构地区 中国协和医科大学
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2010年第2期125-126,共2页 Chinese Journal of Endocrinology and Metabolism
基金 基金项目：首都医学发展科研基金资助（2002-1017）
关键词 白细胞介素6受体基因 多态性 单核苷酸 腰围 体重指数 Interleukin-6 receptor gene Polymorphism, single nucleotide Waist circumference Body mass index
分类号 R589.2 [医药卫生—内分泌]
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参考文献9

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二级参考文献2

共引文献18

同被引文献33

  • 1张明,田林红.白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性[J].中华医学遗传学杂志,2006,23(6):662-664. 被引量：6
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  • 6Wang H, Zhang Z, Chu W, et al. Molecular screening and association analyses of the interleukin 6 receptor gene variauts with type 2 diabetes, diabetic nephropathy and insulin sensitivity. J Clin Endocrinol Metab, 2005,90 : 1123-1129.
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中华内分泌代谢杂志
2010年 第2期

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