免疫磁珠技术在肿瘤学领域的应用

Application of immunomagnetic beads in oncology

免疫磁珠是免疫微球的一种,它是包被有单克隆抗体的球型磁性微粒,可特异性地与靶物质结合使之具有磁响应性,可以保证被分离靶细胞的形态和功能的完整,具有灵敏度高、特异性高、检测速度快、重复性好、操作简单和不需要昂贵的仪器设备等优点,本文就该技术应用于肿瘤细胞的分离、富集与检测以及肿瘤的生物学研究和磁导向治疗、免疫磁性净化等领域的研究进展作一综述。

Immunomagnetic beads,a kind of immunomagnetic microspheres,are the spherical magnetic particles coated with monoclonal antibodies,which can specifically combine with the target material and get magnetic responsiveness and ensure the morphological and functional integrity of the separated target cells.The higher sensitivity and specificity,rapid detection,well repeatability,easier operation and less expensive equipment requirement make this technique more popular.Immunomagnetic beads have gradually been applied to the separation,enrichment and detection of tumor cells,as well as to tumorous biological research and targeted therapy,immunomagnetic purification and other fields.