肾素抑制剂Aliskiren的药理与临床应用
摘要
Aliskiren是一种新型非肽类小分子选择性肾素抑制剂,口服吸收好,每日一次能够有效控制血压,改善心肾功能,且不良反应少,耐受性好,具有良好的应用前景。本文就Aliskiren的药理作用与临床应用作一综述。
出处
《国际泌尿系统杂志》
2010年第2期251-254,共4页
International Journal of Urology and Nephrology
参考文献21
-
1Wood JM, Mainbaum J, Rahuel J, et al. Structure - based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun, 2003, 308(4) : 698 -705.
-
2East Hanover, Novartis NJ. Tecturna (aliskiren) tablets [ prescribing information]. September 2007. http:/www, pharma, us. novartis. corn/product/pi/pdf/tektuma, pdf. Accessed April 16, 2007.
-
3Waldmeier F, Glaenzel U, Wirtz B, et al. Absorption, distribution, metabolism and elimination of direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos, 2007, 35 ( 8 ) : 1418 - 1428.
-
4Campbell DJ. Interpretation of plasma renin concentration in patients receiving aliskiren therapy. Hypertension ,2008,51 ( 11 ) : 15 - 18.
-
5Cada DJ, Levien T, Baker DE. Aliskiren. Hospital Pharmacy,2007, 42(8) : 737 -746.
-
6Cheng JWM. Aliskiren : renin inhibitor for hypertension management. Clin Ther, 2008, 30(3) : 31 -47.
-
7Vaidyanathan S, Reynolds Ch, Yet CM, et al. Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J Clin Pharmacol, 2007, 47 ( 4 ) : 453 - 460.
-
8Vaidyanathan S, Jermany J, Yeh Ch, et al. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and aucasin subjects. Br J Clin Pharmacol, 2006, 62 (6) : 690 - 698.
-
9Parving HH, Persson F, Lewis JB, et al. Aliskiren combined with losartan in type 2 diabetes and nephropaty. N Engl J Med, 2008, 358 (11) : 2433 -2446.
-
10Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II -renin feedback interruption. J Am Soc Nephrol, 2004, 15 (12) : 3126 -3133.
-
1王吉云(摘).降压药Aliskiren获阳性结果[J].国外药讯,2005(8):14-14.
-
2龙凤军.新型抗高血压药Aliskiren[J].心血管病防治知识(学术版),2011,1(5):35-37.
-
3口服肾素抑制剂Aliskiren的安全性与降压效果[J].高血压杂志,2005,13(7):449-449.
-
4杨永超,程华焱.贝那普利联合厄贝沙坦治疗慢性心衰伴蛋白尿的疗效观察[J].中国现代应用药学,2012,29(6):560-563. 被引量:3
-
5宋卫国,李庆珍,朱慧.前列地尔联合左卡尼汀治疗慢性肾衰合并心衰患者78例临床观察[J].江西医药,2013,48(4):344-345. 被引量:11
-
6张雅娉,袁洪,黄志军.肾素抑制剂阿利吉仑[J].中国临床药理学杂志,2012,28(3):221-224. 被引量:5
-
7王吉云(摘).新药临床开发、上市和应用——心脑血管系统药物:Novartis公司的Rasilez效果好[J].国外药讯,2006(7):12-13.
-
8FDA批准AmtumideTM用于治疗高血压[J].中国新药杂志,2011,20(3):193-193.
-
9许文艳,郭晔堃,钟静芬,时惠麟.肾素抑制剂阿利吉仑及其临床研究进展[J].上海医药,2009,30(11):517-520. 被引量:6
-
10冯愉态,邓兴臣.伊贝沙坦治疗高血压病及对心肾功能的影响[J].医学信息(医学与计算机应用),2003,16(5):260-261.