摘要
经由6-甲基嘧啶-2,4-二酮(6-甲基尿嘧啶)在无水乙醇中与甲醛和二乙胺反应,得到5-二乙氨甲基-6-甲基嘧啶-2,4-二酮;研究了影响反应收率的各种因素;利用质谱和核磁共振谱对产品进行了结构鉴定;同时利用小鼠耳肿胀试验测定了产物的抗炎活性.结果表明,所制备的5-二乙氨甲基-6-甲基嘧啶-2,4-二酮具有显著的抗炎活性.
5-diethylaminomethyl-6-methylpyrimidine-2, 4-dihydroxyl-dione was synthesized by way of the reaction of 6-methylpyrimidine 2,4（1H, 3H）-dione with diethylamine and formaldehyde in ethanol. Various factors affecting the reaction yield were studied. The structure of the product was identified by means of mass spectrometry and nuclear magnetic resonance spectrometry. Moreover, mouse ear swelling test was carried out to evaluate anti-inflammatory activity of the product. Results show that product 5-diethylaminomethyl-6-methylpyrimidine-2,4- dihydroxyl-dione has remarkable anti-inflammatory activity.
出处
《化学研究》
CAS
2010年第2期69-71,76,共4页
Chemical Research
关键词
嘧啶
二酮
合成
抗炎活性
pyrimidine
dione
synthesis
anti-inflammatory activity
