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谷胱甘肽过氧化物酶模拟物6-CySeCD对过氧化氢诱导小鼠成纤维细胞损伤的保护作用 被引量：3

GPX Mimic 6-CySeCD Protecting Mouse Fibroblast Cell NIH3T3 from Damage Induced by H_2O_2
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摘要 考察不同剂量的H2O2作用于小鼠成纤维细胞(NIH3T3)后,细胞脂质过氧化、存活率、DNA片段化的变化情况,并研究谷胱甘肽过氧化物酶(GPX)的模拟物6A,6B-环己胺-6A′,6B′-硒桥联-β-CD(6-CySeCD)抗H2O2诱导小鼠成纤维细胞损伤的能力.结果表明:H2O2对NIH3T3细胞有严重损伤;6-CySeCD能有效保护细胞,防止紫外线引起的损伤. The antioxidant effect of 6A,6A＇-cyclohexylamine-6B,6B＇-selenium-bridged-β-cyclodextrin （6-CySeCD）, a new mimic of glutathione peroxidase （GPX） , was confirmed with a model system in which mouse fibroblast cell NIH3T3 were damaged by H2PO2. The cell damage was characterized in terms of the lipid peroxidation of the cells, cell viability, DNA lysis rate. The injury effects of H2 O2 and protection effects of 6-CySeCD on the cells were studied via the model system. The results show the 6-CySeCD could be able to protect cells from the damage induced by H2O2.
作者 徐亚维 闫岗林 龚平生 牟颖 罗贵民 杨佳 吕绍武
机构地区 吉林大学分子酶学工程教育部重点实验室 吉林农业科技学院生物工程系 长春西诺生物科技有限公司
出处 《吉林大学学报（理学版）》 CAS CSCD 北大核心 2010年第2期329-332,共4页 Journal of Jilin University:Science Edition
基金 国家自然科学基金(批准号:20572035 30970608) 吉林大学基本科研业务费项目(批准号:200903093)
关键词 谷胱甘肽过氧化物酶(GPX) 模拟物 6-CySeCD 过氧化氢 成纤维细胞 glutathione peroxidase （GPX） mimic 6-CySeCD hydrogen peroxide fibroblast cell
分类号 R392.11 [医药卫生—免疫学]
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参考文献10

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共引文献4

同被引文献48

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吉林大学学报（理学版）
2010年 第2期

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