麝香保心丸长期用药对冠心病患者血管内皮功能改善作用的研究

Improvement effect on vascular endothelial function of Shexiang Baoxin Pill's long-term administration in patients with coronary heart disease

目的:观察长期服用麝香保心丸(SXBXP)对冠心病患者血管内皮功能的改善作用。方法:入选80例冠心病患者随机分为SXBXP组和对照组,两组均给予冠心病常规治疗,SXBXP组加服SXBXP.2丸/次,3次/日,至少6月。测定肱动脉血流介导内皮依赖性舒张功能(FMD)评价两组患者血管内皮功能。分别在入选时,随访3个月、6个月、18个月时检测FMD,并同时检测血一氧化氮(NO)、一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)、内皮素(ET)等血管内皮功能相关因子。结果:随访期间SXBXP组FMD、NO、NOS、SOD、ET均较对照组改善,FMD、SOD水平于随访3个月时达统计学显著差异标准(P<0.05),NO、NOS、ET水平于随访6个月时达统计学显著差异标准(P<0.05)。随访18个月时,SXBXP组中继续服用SXBXP的患者FMD、NO、NOS、SOD水平明显高于对照组(P<0.05)。结论:冠心病患者长期服用麝香保心丸6个月可明显改善血管内皮功能。

AIM：To observe the improvement in the endothelial function of patients with long-term use of Shexiang Baoxin Pill（Moschus,Ginseng extract,Calculus bovis,Cortex cinnamomi,Styrax,Venenum bufonis,and Borneolum Syntheticum）（SXBXP）.METHODS：Eighty patients with CHD were randomly assigned into the SX-BXP group and the control group.Two groups were controlled with the usual treatment.SXBXP 2 pills,po.tid.were taken in the SXBXP group and continued for at least 6 months.The ultrasound assessment of endothelial-dependent flow-mediated vasodilation（FMD） of the brachial artery was applied in the 3rd,6th and 18th and simultaneous determination of nirtogen oxides（NO）,nitricoxide synthase（NOS）,superoxide dismutase（SOD）,endothelin（ET） was made.RESULTS：Follow-up checkups revealed that the level of FMD and SOD in the 3rd month,the level of NO,NOS and ET in the 6th month in SXBXP group were better than those in the control group at the significant level（P〈0.05）.Patient keeping on taking SXBXP up to the 18th month,the obvious improvement in the level of FMD,NO,NOS and SOD was showed（P〈0.05）.CONCLUSION：Administration of SXBXP could improve endothelial function in the CHD patients significantly.