癌迪针剂对荷瘤小鼠免疫功能的影响

The effect of AD injection on immune functions in tumor-bearing mice

目的:研究癌迪针剂对肿瘤的作用效果及其抗肿瘤免疫效应机制。方法:选用H22肝癌荷瘤小鼠注射癌迪针剂7天后,观察荷瘤小鼠肿瘤抑制率、胸腺、脾脏指数、淋巴细胞转化功能、腹腔巨噬细胞吞噬功能、TNF活性、IL-2及血清IFNα-水平。结果:癌迪针剂可明显抑制荷瘤小鼠肿瘤生长;能提高荷瘤小鼠的淋巴细胞转化功能;可增强巨噬细胞吞噬活性和TNF活性;能提高IL-2和IFNα-水平。结论:癌迪针剂能明显抑制荷瘤小鼠肿瘤生长,增强机体的免疫功能。

Objective：In order to study the antitumor effect of AD injection and its inununological mechanisms. Methods：Liver cancer H22-bearing mice were treated with AD injection and 7 day＇s later to observe the effect of AD injection on the inhibitory rate of tumor, indexes of thymus and spleen, lymphocytes transformation function, phagocytosis of the peritoneal macrophage, activity of TNF, the level of IL-2 and IFN-α in serum. Results： AD injection could inhibit the growth of tumor in beating mice significantly and promote the transformation function of lymphocytes and enhance the peritoneal macrophage phagocytosis and the activities of TNF. AD injection could improve the level of IL-2 of spleen cells and IFN-α in serum. Conclusion：These results suggested that AD injection could obviously inhibit the growth of tumor and enhance the immune functions in bearing mice.