心衰与基因的研究进展
摘要
各种基因与疾病的相关研究广泛开展后,人类已经进入基因时代。就心力衰竭(简称心衰)的基因组学研究也在日渐增多,一些基因已经被研究表明与心力衰竭的治疗和预后有关联,本文就相关研究进展作一综述。
出处
《浙江临床医学》
2010年第3期321-322,共2页
Zhejiang Clinical Medical Journal
二级参考文献8
-
1Bristow MR. Why does the myocardium fail? insights from basic science.Lancet, 1998, 352 (suppl Ⅰ): S14-S18.
-
2Green SA, Turki J, Innis M, et al. Amino-terminal polymorphisms of the human β2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry, 1994, 33: 9414-9419.
-
3Reihsaus E, Innis M, MacIntyre N, et al. Mutations in the gene encoding for the β2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol, 1993, 8: 334-339.
-
4Green SA, Cole G, Jacinto M, et al. A polymorphism of the human β2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptos. J Biol Chem, 1993,268: 23116-23121.
-
5Liggett SB. Molecular and genetic basis of β2-adrenergic receptor function. J Allergy Clin Immunol, 1999, 103: S42-S46.
-
6Turki J, Lorenz JN, Green SA, et al. Myocardial signaling defects and impaired cardiac function of a human β2-adrenergic receptor polymorphism expressed in transgenic mice. Proc Natl Acad Sci, 1996, 93:10483-10488.
-
7Liggett SB, Wagoner LE, Craft LL, et al. The Ile164 β2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. J Clin Invest, 1998, 102: 1534-1539.
-
8Wagoner LE, Craft LL, Singh B, et al. Polymorphisms of the β2-adrenergic receptor determine exercise capacity in patients with heart failure.Circ Res, 2000, 86: 834-840.
共引文献3
-
1梅啸,彭健.肾素—血管紧张素系统基因多态性与慢性心力衰竭关系的研究进展[J].中国心血管病研究,2005,3(1):76-79. 被引量:14
-
2罗礼云,彭健.肾素-血管紧张素系统及交感神经系统基因多态性与慢性心力衰竭个体化治疗[J].国际心血管病杂志,2007,34(2):122-126. 被引量:5
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3王保功,刘华玲,王瑞丽,王学惠.β2-肾上腺素能受体基因多态性与慢性心力衰竭后室性心律失常的关系[J].实验与检验医学,2020,38(1):17-20. 被引量:3
-
1东初.生物制药“遭遇”基因时代[J].医药世界,2001(12):46-46.
-
2曾良驹.苦辣酸甜皆是抗癌药[J].医药与保健,2009(4):61-61.
-
3贾汉.基因与疾病研究进展[J].地方病通报,2002,17(1):80-82.
-
4李芬,陈进伟,高洁生,卢放根.类风湿关节炎的常见药物基因组学研究进展[J].中华风湿病学杂志,2012,16(12):841-844. 被引量:2
-
5日本热衷医用蛋白质[J].化工文摘,2001(2):46-46.
-
6石盼盼,何功浩,徐贵丽.组胺基因组学研究进展[J].中国临床药理学与治疗学,2012,17(6):703-708. 被引量:1
-
7李桂英,董博.线粒体基因与疾病的研究进展[J].现代医药卫生,2008,24(12):1836-1838.
-
8易洪刚,陈峰,于浩,赵杨,娄东华.病例同胞对照设计[J].中华流行病学杂志,2006,27(2):170-173. 被引量:4