脑梗死患者血清叶酸和维生素B_(12)水平的测定及其临床意义

The relationship and the clinical significance between the serum folate and vitaminB12 levels in patients with cerebral infarction

目的探讨血清叶酸、维生素B12与脑梗死的关系及其临床意义。方法采用电化学发光免疫分析技术测定45例脑梗死患者和50例健康人血清叶酸、维生素B12的水平。结果急性脑梗死患者血清叶酸、维生素B12水平明显低于对照组(P<0.001,0.05),重型患者血清叶酸、维生素B12水平明显低于中型及轻型患者(P<0.01,0.01)。结论血清叶酸、维生素B12水平降低与脑梗死的发生有关,可能是其中又一危险因子。

Objective To study the relationship and the significance between the serum levels of folate and vitamin Bl2 with cerebral infarction. Methods The levels of folate and viamin B12 in serum samples of 45 patients with cerebral infarction and 50 healthy people were determined by electro-ebemiluminescence immunoassay. Results The levels of folate and vitamin B12 in serum of patients with acute cerebral infarction group were significantly lower than healthy people （P 〈 0. 001,0.05）. In severe patients, the folate levels decreased significantly （ P 〈 0.01,0.01 ） as compared with middle and mild types. Conclusion The low serum folate and vitamin B12 were associated with the cerebral infarction, it maybe one of the risk factors for cerebral infarction.