Ebp1蛋白在贲门癌组织中的表达及临床意义

Ebp1 expression level and clinical significance in human cardiac cancer

目的研究人贲门癌组织中Ebp1蛋白表达及其与临床参数的关系。方法采用免疫组织化学染色对120例贲门癌患者的癌组织和配对的癌旁正常组织中Ebp1蛋白表达水平进行测定。结果94(78.33%)例贲门癌样本中Ebp1蛋白表达下调。单因素分析显示,与Ebp1蛋白表达水平相关的临床参数有:家族史、淋巴结转移、肿瘤体积、分化程度和临床分期。有家族史组Ebp1蛋白表达水平显著低于无家族史组,淋巴结转移组Ebp1蛋白表达水平显著低于淋巴结未转移组。肿瘤体积越大、分化程度越低、临床分期越高,Ebp1蛋白表达水平越低。多因素分析显示,在贲门癌中淋巴结转移和临床分期均是Ebp1表达的保护因素。结论Ebp1在贲门癌发展过程中起重要作用;可能作为贲门癌病情进展的监测、转移潜能及预后评估方面的一个靶基因。

Objective To investigate Ebpl expression levels and their relations to clinical variables in human cardiac cancer. Methods Ebpl expression levels were tested in one hundred and twenty cardiac cancer tissues and their matched normal cardiac tissues by immanohistochemistry staining. Results 94（78.33% ）samples were found down-regulation of Ebpl in cardiac cancer com- paring to the matched normal cardiac tissues. The univariate analysis showed that Ebpl protein expression levels had significant associ- ation with family history, metastasis, tumor size, diffe^entiation and TNM stage. Protein expression level of Ebpl in the patients whose family member had Cancer were significantly lower than those whose family member did not; protein expression level in metastasis tis- sues was significantly lower than in those non-metastasis ones; protein expression level was lower in greater tumor, poor differentiation and higher TNM stage. The multiple factor analysis showed that metastasis and TNM stage were both protect factors for Ebpl in cardiac cancer. Conclusion Ebpl plays an important role in the procession of cardiac cancer and might serve as a valuable target in monitoring of cardiac disease, metastatic potential and prognosis.