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术中放疗对保乳患者伤口引流液内GRO-1、VEGF的影响 被引量：2

Quantitative Analysis of GRO-1 and VEGF in the Wound Fluid of Patients after Breast-conserving Surgery and Intraoperative Radiotherapy
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摘要 目的研究早期乳腺癌保乳手术术中电子射线照射,对保乳患者伤口引流液内GRO-1和VEGF的影响。方法采取随机方法,将60例保乳手术患者分为对照组和试验组,每组30例,对照组患者单纯行保乳手术,试验组患者行保乳手术并术中辅以电子射线照射。收集两组患者术后24h伤口引流液。应用ELISA方法,检测引流液内GRO-1和VEGF含量。结果对照组患者引流液内GRO-1和VEGF的含量分别为(50.08±14.09)pmol/l和(427.16±20.18)ng/l,两者在表达上呈正相关性(γ=0.817,P<0.01);实验组患者引流液内GRO-1和VEGF的含量分别为(15.64±2.80)pmol/l和(206.55±6.34)ng/l,两者在表达上呈正相关性(γ=0.449,P<0.05)。与对照组比较,试验组GRO-1和VEGF含量均明显下降(P<0.01)。结论术中电子射线照射明显降低保乳手术患者伤口引流液内GRO-1和VEGF的含量,并且两者表达呈正相关性。 Objective To investigate the effects of growth-regulated oncogene-1 （ GRO-1 ） and vascular endothelial growth factor（VEGF） in the wound fluid of breast -conserving surgery patients by intraoperative radiotherapy with electrons during breast-conserving surgery of early breast cancer. Methods 60 breast-conserving surgery patients were randomly divided into control group and trial group. Control group contained 30 patients who received single breast-conserving surgery. Trila group contained the renmain 30 patients who received breast-conserving surgery and ELIOT. All wound fluid was then collected. The levels of GRO-1 and VEGF in every patient were determined by ELISA. Results The levels of GRO-1 and VEGF in control group were respectively （50.08 ± 14.09 ）pmol/1 and （427.16± 20. 18 ）ng/1, and the expression of GRO-1 and VEGF was positive correlated（ X^2 =0. 817 ,P 〈0.01 ）. The levels of GRO-1 and VEGF in trial group were respectively （ 15.64 ±2.80） pmol/1 and （206.55 ±6.34）ng/1,and the expression of GRO-1 and VEGF was positive correlated（γ =0. 449,P 〈0.05）. Conclusion Intraopera- tive radiotherapy with electrons could obviously degrade the levels of GRO-I and VEGF in the wound fluid of breast-conserving surgery patients, and the expression of GRO-1 and VEGF was positive correlated.
作者 刘小健 周士福 周洪伟 时伟峰 戴启明 孙春雷 孟东
机构地区 苏州大学附属第四医院乳腺中心
出处 《实用癌症杂志》 2010年第2期129-132,共4页 The Practical Journal of Cancer
关键词 乳腺癌 伤口引流液 生长相关性癌基因-1 血管内皮生长因子 Breast cancer Wound fluid Growth-regulated oneogene-1 （ GRO-1 ） Vascular endothelial growth factor （VEGF）
分类号 R737.9 [医药卫生—肿瘤]
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参考文献13

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共引文献17

同被引文献26

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实用癌症杂志
2010年 第2期

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