超分子双膦配体的构筑及应用研究进展

Advance in Preparation and Application of Supramolecular Bidentate Phosphorus Ligands

超分子双膦配体是一类新兴起的基于非共价键作用构筑的双膦配体,近年来引起人们的重视.与传统的共价键连接的双膦配体相比,利用非共价相互作用的可逆性和选择性,超分子双膦配体具有合成简便,组合灵活,易于合成超分子配体库,并利用组合化学的方法对催化体系进行优化和筛选等优点.详细综述了近几年发展的基于氢键、配位键、主客体作用和静电作用等弱相互作用的超分子双膦配体,重点讨论了它们的构建方法以及在不对称催化反应中的应用,并对其发展前景进行了展望.

Supramolecular bidentate phosphorus ligands formed by self-assembly of monodentate ligands containing complementary noncovalent binding sites have been attracting great attention recently. In contrast to the classical bidentate ligands, supramolecular ligands are greatly easy to prepare and modify as a result of the reversibility and selectivity of noncovalent interactions. Another important feature of supramolecular ligands is their huge potential to provide ligand library for combinatorial approaches and high throughput screening experimentation. The synthesis and application to asymmetric catalysis of supramolecular biden- ：ate ligands formed by hydrogen bonding, coordinative interactions or host-guest interactions are reviewed.