原发性肝癌并发胆结石

Relationship of primary liver cancer and bilestone

目的：观察研究原发性肝癌（PHC）并发胆结石发生率及其发生机理。方法：采用腹部B超和CT影像检查确定PHC患者并发胆结石。结果：并发胆结石发生率：PHC组22％（36／152）和继发性肝癌（MHC）组45％（2／44）比较有明显差异。P＜0．05，PHC组和肝硬化（LC）组25％（14／56）比较无明显差异。结论：并发胆结石，PHC组远远高于MHC组。其原因可能与两组在门脉高压和肝功能损害存在明显差异有关。PHC和LC一样，由于门脉压增高一般都有胆囊壁充血水肿和通透性增加，同时，肝细胞受损，特别是胆红素升高引起胆汁中胆固醇、胆红素和磷脂比例和量发生改变，生成以胆红素为主的混合性结石。

Objective: To determine the occurrence rate of bilestone in patients with primary liver cancer(PLC). METHOD:Ultrasound and CT were used to diagnose bilestone in 158 patients with PLC as well as in 100 patients with cirrhosis or rnetastatic liver cancer (MLC ) as control group. Liver function was also detected. RESULTS: It was found that the bilest0ne positive rate in PLC group was 22%,which was significantly higher than that in MLC group(4. 5% ) (p0. 05),but not in the cirrhosis group (25% ) (p0.05). CONCLUSION:The patients with PLC were easily as sociated with bilestone. Risen bilirubin may be a highly risk factor for bilestone.