X线放射治疗皮肤癌

X-RAY THERAPY IN THE MANAGEMENT OF SKIN CANCER

目的：评价Ｘ线放射治疗在皮肤癌治疗中的意义。材料与方法：法国巴黎第十二大学享利·孟德尔医院肿瘤科于１９８９～１９９５年共放射治疗１１４例皮肤癌，其中９９例（８６．８％）为基底细胞癌，１５例（１３．２％）为鳞癌。根据ＴＮＭ分期（ＵＩＣＣ１９８７）和ＡＪＣ分期系统，８６例（７５．４％）为Ｔ１，２６例（２２．８％）为Ｔ２，２例（１．８％）为Ｔ３。均用４５～１００ＫＶＸ线做局部放疗，总剂量为３３Ｇｙ，分３次照射（第１天，第８天，第１５天）。结果：肿瘤控制率为９８．２％（１１２／１１４），２例（１．８％）在放射野边缘复发。耐受性非常好、好及一般者分别为３６．０％，４８．２％和１５．８％。结论：Ｘ线治疗皮肤癌具有效果好、价格便宜、应用简单等优点。

Purpose:To evaluate the significance of X-ray therapy in the management of skin cancer.Materials and Methods:Between 1989 and 1995,114 patients with skin carcinomas were treated in Cancerology Department of Henri Mondor University Hospital with cutaneous irradiation.There were 99(86.8%)basal cell carcinomas and 15(13.2%) squamous cell carcinomas. According TNM classification (UICC 1987)and AJC Staging System,there were 86(75.4%) T 1 tumors,26(22.8%)T 2,and 2(1.8%) T 3 carcinoma.All 114 Lesions were treated with localized irradiation using 45～100 KV X-ray energy.The total prescribed dose was 33Gy in 3 fractions (days1,8,and 15).Results:Objective tumor control rate was 98.2%(112/114).There were observed 2 local recurrences(1.8%) at the border of the field.The tolerance was excellent in 36%,good in 48.2%,and satisfactory in 15.8% of the cases.Conclusion:X-ray radiotherapy is highly efficacious,cheap and easy for application method of treat ment for basal cell and spinal cell skin carcinomas, which offer excellent cosmesis.