TGF-β和P53蛋白在前列腺癌组织中的表达及其意义

Expressions of P53 and TGF-β in prostatic carcinoma tissue and their significances

目的:探讨转化生长因子-β(TGF-β)和P53蛋白在前列腺癌组织中的表达及其临床意义。方法:应用免疫组织化学SP法检测36例前列腺癌标本组织中TGF-β和P53蛋白表达情况。结果:36例前列腺癌标本组织中高、中、低分化癌分别为10、16和10例。TGF-β在高、中和低分化前列腺癌组织中的阳性表达率分别为30%(3/10)、37.5%(6/16)和70.0%(7/10);P53蛋白在高、中和低分化前列腺癌组织中的阳性表达率分别为20%(2/10)、25.0%(4/16)和50%(5/10)。TGF-β和P53蛋白在高、中分化前列腺癌组织中的表达强度均低于在低分化前列腺癌组织(P<0.05)。结论:TGF-β和P53蛋白阳性表达率和表达强度与前列腺癌分化程度有相反的变化趋势,提示检测TGF-β与P53蛋白的表达可协助鉴定前列腺癌分化程度并评估预后。

Objective To study the expressions of TGF-β and P53 protein in prostatic carcinoma tissue and their clinical significances.Methods Immunohistochemical method was used to detect the expressions of TGF-β and P53 protein in 36 cases of prostatic carcinoma.Results 36 cases of prostatic carcinoma included 10 cases of well differentiation,16 cases of moderate differentiation,10 cases of poor differentiation.The positive expression rates of TGF-β in well,moderately,poorly differented prostatic carcinoma tissues were 30%（3/10）,37.5%（6/16）,and 70%（7/10）;the positive expression rates of P53 protein in well,moderately,poorly differented prostatic carcinoma tissues were 20%（2/10）,25%（4/16）,and 50%（5/10）.The expression rates of TGF-β and P53 protein in well and moderately differented prostatic carcinoma tissues were lower than those in poorly differented prostatic carcinoma tissues（P〈0.05）.Conclusion The expressions of TGF-β and P53 have a negative correlation with the differented degree of prostatic carcinoma and the expressions of TGF-β and P53 may help to judge the pathologic grade and predict the prognosis of prostatic carcinoma.