摘要
目的研究癌性Lambert-Eaton肌无力综合征(LEMS)临床及电生理特征。方法回顾性地评价了4例病理证实的癌性LEMS(例1、2为小细胞性肺癌,例3为肾上腺癌,例4为乳腺癌)的临床和电生理资料。结果面神经、腋神经及尺神经重复电刺激示,诱发电位起始波幅减小(0.4~0.7mV);5Hz以下低频刺激后波幅递减16%~54%(对照:小于15%),但在10Hz以上高频刺激后波幅递增120%~657%(对照:小于65%);例2和例3肌电图和神经传导速度测定示,多发周围神经源性损害,以感觉神经纤维轴索损害为主。结论观察结果表明,部分癌性LEMS患者的神经肌肉接头和周围神经可同时受累。
To study the clinical and electrophysiological characteristics of carcinomatous Lambert--Eaton myasthenic syndrome (LEMS ). Methods Tase 3 with adrenal cancer, and case 4 with breast cancer ) were studied. Results Repeatitive stimulation of the facial, axilliary and/or niner nerve showed diminished amplitude of initial response (0. 4--0. 7 mV); Amplititude of the response at less than 5 Hz stimulation was diminished 16ary and/or niner nerve showed diminished amplitude of initial response (0.4- 0. 7 mV); Amplititude of the response at less than 5 Hz stimulation was diminished 16%-54% (control: less than 15% ) but that at more than 10 Hz stimulation increased 120%-657% (control: less than 65%). EMG and NCV showed multiple peripheral neuropathy with predominant sensory a-conal lesion in the 2nd and 3rd cases. Conclusion Our findings indicated that both the neuromuscular junctions and the peripheral nerves might be involved in some carcinomatous LEMS.
出处
《中国神经免疫学和神经病学杂志》
CAS
1998年第4期229-232,共4页
Chinese Journal of Neuroimmunology and Neurology
关键词
癌性肌无力
肌无力综合征
电生理
carcinoma
Lambert-Eaton myasthenic syndromel nerve repetitive stimulation