生理药动学模型预测二甲双胍在人体内的动力学过程

Predicted Kinetica Process of Metformin in the Body Using Physiology-based Pharmacokinetic Model

目的:建立二甲双胍在人体内的血流限速生理药动学模型,预测正常和病理条件下,药物在人体内的动力学过程。方法:应用ACSLXtreme与3P97软件进行求解模拟,并将模拟值和文献值比较分析。结果:模型模拟二甲双胍的药动学参数为:Cmax1.18μg/mL,tmax2.33h,t1/2a2.84h,AUC8.08μg/(mL·h-)与文献报道值基本吻合。结论:生理模1型能够准确预测二甲双胍在机体内的动力学过程。

Objective： To develop a flow-limited, physiology based pharmacokinetie （PBPK） model for predicting kinetica process of Metformin in the body trader healthy and pathological conditions. Methods： The simulation equations were solved by the ACSLX treme software and the simulated concenlrations were compared with the measaued ones. Results： Simulated pharmacokinetic parameters of Mefformin were ： Cmax 1.18μg/mL, tmax 2.33 h, t1/2a, 2.84 h, AUC 8.08μg/（h·mL-1） and these parameters were according to the reported values. Conclusion： PBPK can accurately predict the kinetica process of the drug in the body.