286株流感嗜血杆菌分布特点和耐药分析

Analysis on Distribution and Antibacterial Resistance of 286 Strains of Haemophilus Influenzae

目的:调查镇江市第一人民医院流感嗜血杆菌的临床分布及耐药性情况。方法:按照标准方法分离流感嗜血杆菌并进行药物敏感试验及其检测。结果:分离出的286株流感嗜血杆菌对氨苄西林、复方新诺明、阿奇霉素和左氧氟沙星的耐药率较高,分别达46.50%,57.34%,44.75%和40.91%;对头孢克洛、头孢丙烯、氨苄西林/舒巴坦、氨曲南和美洛培南的敏感率均在80%以上。结论:头孢克洛、头孢丙烯、氨苄西林/舒巴坦、氨曲南和美洛培南是治疗流感嗜血杆菌感染的有效抗生素,但应加强对流感嗜血杆菌的培养及耐药性监测工作。

Objective： To investigate the dislribution and drug resistance situation of the Haemophilus influenzae species islated from the No.1 People＇s Hospital of Zhenjiang. Methods： Haemophilus influenzae were isolated and β-laclamases were detected according to standard methods. Results： Totally 286 swains of Haemophilus influenzae isolated and resistmace rate of Arnpicillin, SMZ/TMP, azithromycin and levofloxacin were 46.50%,5, 57.34%, 44.75% and 40.91%, respectively; and sensitivity to cefaclor, cefprozil, ampicillin/sulbactam, aztreconam and meropenem was all more than 80%. Conclusion： Cefaclor, cefprozil, ampicillin/stdbacmm, aztreonam and meropenem were the most effective antibiotics to cure infection caused by Haemopln＇lus influenzae, and it is very important to strengthen the Haemophilus species culture and drug resistance monitoring.