70例胎膜早破孕产妇病原学药敏分析

Analysis of Drug Sensitivity in 70 Patients with Premature Rupture of Membrane

目的:分析孕产妇胎膜早破病原体与药敏试验,了解病原体与耐药性分布。方法:采用2004年NCCLS标准与K-B纸片法操作规程,质控菌:葡萄球菌(ATCC25923)、大肠埃希菌(ATCC25922)、铜绿假单胞菌(ATCC27853)及肺炎克雷伯菌(ATCC700603)作对照,观察70例胎膜早破孕产妇细菌感染治疗情况。结果:70例胎膜早破孕妇中细菌检测率90.00%(63/70),其中足月妊娠孕妇11.43%(8/70);经病原学检测,其中葡萄球菌51.43%(36/70);大肠埃希菌18.57%(13/70);铜绿假单胞菌7.14%(5/70);肺炎克雷伯菌12.86%(3/70)。观察组胎膜早破与对照组治愈率比较,有显著性差异(P<0.001)。结论:针对药敏试验结果合理选用抗菌药物规范治疗,可降低胎膜早破感染的发生率。

Objective： To Analyze the pathogens and antimicrobial susceptibility testing of premature rapture of membrane in maternal, to understand the distribution of pathogens and drug resistance. Methods： Using 2004 NCCLS standards and operational procedures K-B disk diffusion method. Quality control strains： Staphylococcus aureus（ATCC25923）, Escherichia co/i（ATCC25922）, Pseudomonas aeruginosa（ATCC27853） and Klebsiella pneumoniae（ATCC700603） As control, observation of 70 cases of premature rapture of membranes treatment of bacterial infections in pregnant women. Results： The positive rates are 90.00%（63/70） of 70 patients-with bacterial premature rupture of membrane, full-termpregnancy 11.43%（8/70）. As a result of etiology examination, Staphvlococcus 51.43%（36/70）, Escherichia coli 18.57% （13/70）, Pseudomonas aeruginosa 7.14%（5/70）, Klebsiella pneumoniae 12.86%（3/70） of them. There was a significant difference（P〈0.001） of observation group cure rate of premature rupture of membranes compared with the control group. Conclusion： Drugs should be chosen rationally according to antimicrobial susceptibility test results so as to reduce the incidence of infections in premature rupture of membranes.