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对ASC-H的妇女行高危人乳头状瘤病毒DNA检测的临床意义 被引量：2

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摘要 目的探讨高危人乳头瘤病毒DNA(hrHPV DNA)辅助检测对宫颈非典型鳞状上皮,不除外高度鳞状上皮内病变(ASC-H)女性疾病的风险评估。方法对1187例ASC-H妇女进行hrHPV感染的流行病学和组织病理学资料调查及分析。结果在277,400例宫颈细胞学检查中判读为ASC-H的1187例中,589例(49.6%)hrHPV DNA检测结果为阳性。对其中505例的组织病理学随访,32.7%hrHPV DNA阳性者系宫颈高度鳞状上皮内病变(CIN2/3),hrHPV DNA阴性妇女仅有1.2%呈CIN2/3改变。hrHPV DNA检测结果提示CIN2/3改变的阳性预测值(PPV)、阴性预测值(NPV)、敏感性和特异性分别是32.7%、98.8%、96.6%和58.6%。该PPV约是单纯细胞学结果ASC-H预测CIN改变的2倍。宫颈/移行区(EC/TZS)样本的存在与否并不影响hrHPV DNA或CIN2/3级的检出率。结论对细胞学判为ASC-H的妇女行hrHPV DNA检测具有较高的临床价值。对hrHPV DNA阴性患者可单纯行常规细胞学随访和hrHPV DNA检测,而不需要进行阴道镜检查,尤其是对40岁以上妇女。
作者 Sudeshna Bandyopadhyay R.Marshall Austin David Dabbs Chengquan Zhao 白雪娟 杨敏 赵澄泉 傅新文
机构地区 美国匹兹堡大学医疗中心Magee妇产医院病理科 中国人民解放军总医院 美国匹兹堡大学医疗中心Magee妇产医院 江西省人民医院
出处 《实验与检验医学》 CAS 2010年第1期3-5,24,共4页 Experimental and Laboratory Medicine
关键词 人乳头状瘤病毒DNA检测 ASC 高度鳞状上皮内病变 妇女 临床意义 宫颈细胞学检查 高危 组织病理学
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献12

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同被引文献11

  • 1赵澄泉,杨敏.妇科细胞病理学诊断与临床处理[M].北京:科学技术出版社,2011.
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  • 3Li S, Hu T,Lv W, et al. Changes in prevalence and clinical characteristics of cercervical cancer in the People' Republic of China:a study of 10 012 cases from a Nation- wide Working Group [J]. Oncologist,2013,18 (10):1101 - 1107.
  • 4International Agency for Research on Cancer Globacan 2012 clatabase [l].World Health Organisation, 2012-10- 12(2), [2014-03 -20].http://www-dep.iarc.ff/.
  • 5DianeSolomon.RiluNayar.子宫颈细胞学Bethesda报告系统定义标准和注释[M].第二版.黄受方等译,北京.人民军医出版社,2004,37-40.
  • 6Sherman ME, Castle PE, Solomon D, et d. Cervical Cytology of atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion(ASC-H):Characteris- tics and histologic outcomes[J].Cancer(cytopathol),2006, 108:298-305.
  • 7Cohen D, Austin RM, Gilbert C, et al. Follow-up out- comes in a large cohort of patients with human papillo- mavirus-negative ASC-H cervical screening test results[J]. AmJ Clin Pathol,2012,138(4):517-523.
  • 8Davey DD, Greenspan DL, Kurtycz DF, et al. Atypical squamousceUs,cannot exclude high -grade squamous in- traepithelial lesion:review of ancillary testing modalities and imphcations for follow-up [J]. J Low Genit Tract Dis, 2010,14(3) :206-214.
  • 9Ahn S, Lee YY, Sung JY, et ol. Body mass index and out-come of asc-hinterpreted cervical smears in post- menopausal women[j]. Acta Cytologica, 2012, 56(3):259- 265.
  • 10吕世琪,张金良,闫奇.乙肝五项指标与荧光定量PCR检测血清HBV-DNA含量联合运用[J].实验与检验医学,2011,29(6):641-642. 被引量：6

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实验与检验医学
2010年 第1期

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