良性前列腺增生磁共振扩散张量成像的初步研究

Diffusion tensor imaging in evaluation of benign prostatic hyperplasia:preliminary study

目的探讨磁共振扩散张量成像(DTI)在评估良性前列腺增生(BPH)和正常外周带结构差异的应用价值。方法研究对象为经病理证实的25例BPH患者,DTI成像采用SIEMENSSonata1.5T超导成像仪和腹部相控阵线圈,应用Leonardo工作站相应的软件进行数据处理。记录BPH和正常外周带(PZ)的FA值和平均ADC值,绘制相应参数图和纤维示踪图像。对比不同感兴趣区的成像指标的差异。结果正常外周带和BPH的FA值分别为0.16±0.03和0.23±0.04(P<0.05),平均ADC值分别为(1.85±0.34)×10-3mm2/s和(1.37±0.27)×10-3mm2/s(P<0.05)。PZ区和BPH区的纤维方向、形态和数量存在明显差异。结论DTI能评估BPH和PZ的结构差异,可作为BPH术前评估的影像学手段。

Objective： To investigate the value of diffusion tensor imaging （DTI） in evaluating the structure of normal peripheral zone （PZ） and benign prostate hyperplasia （BPH）. Materials and Methods： Twenty five patients with BPH were included in this study. DTI was performed using a 1.5 Tesla superconducting magnetic scanner （SIEMENS） equipped with a pelvic phased-array multi-coil. All data were transferred to SIEMENS Leonardo Workstation and different regions of interest （ROI） of PZ and BPH were drawn by a radiologist. Using the DTI card, the fractional anisotropy （FA） and mean apparent diffusion coefficients （ADC） of DTI were calculated and the corresponding index maps were produced. Results： The FA of PZ and BPH were 0.16±0.03 and 0.23±0.04, respectively. The FA of PZ were lower than that of BPH （P〈0.05）. The mean ADC value of BPH （1.37±0.27×10^-3 mm^2/s） was lower than that of PZ （1.85±0.34×10^-3 mm^2/s） （P〈0.05）. The directions, length and amount of BPH were different from those of PZ. Conclusion： DTI can be used to evaluate the three-dimensional architecture of PZ and BPH, which has the potential to provide useful information for the treatment of BPH.