胃癌中HIF-1a、VEGF及Glut1的表达

HIF-1a,VEGF and Glut1 protein expression in gastric carcinoma

目的探讨HIF-1a、VEGF及Glut1在胃癌中的表达及其临床病理意义。方法应用免疫组织化学SP法检测120例胃癌组织中HIF-1a、VEGF及Glut1的表达。结果HIF-1a、VEGF及Glut1在胃癌组织中的阳性表达率分别为70%、61.7%、69.2%,明显高于癌旁组织,差异具有统计学意义(P<0.01)。HIF-1a、Glut1的阳性表达与组织学类型、浸润深度、淋巴结转移及临床分期有关(P<0.05);VEGF的阳性表达与组织学分级、浸润深度、淋巴结转移及临床分期有关(P<0.05);HIF-1a分别与VEGF及Glut1在胃癌组织中表达存在密切的相关性(rs1=0.681,P<0.001;rs2=0.626,P<0.001)。结论HIF-1a、VEGF及Glut1的阳性表达可以作为胃癌侵袭转移潜能的生物学指标,且这些指标的表达对于临床早期干预治疗具有重要的指导意义。

Objective To study the significance of the expression of HIF-1a,VEGF and Glut1 in gastric carcinoma and explore the correlation between the expression of HIF-1a,VEGF and Glut1 protein in gastric carcinoma.Methods The expression of HIF-1a,VEGF and Glut1 protein were detected with SP immunohistochemical method in 120 patients with gastric carcinoma.Result The positive expression rates of HIF-1a,VEGF and Glut1 in gastric cancer were 70%,61.7% and 69.2% respectively,and significantly higher than those in gastric paracarcinous tissue.HIF-1a,Glut1 expression correlated with histopathologic type,depth of invasion,lymph node metastasis,TNM stage（P〈0.05）;VEGF expression correlated with cell differentiation,depth of invasion,lymph node metastasis,TNM stage（P〈0.05）;Glut1 expression correlated with histopathologic type,depth of invasion,lymph node metastasis,TNM stage（P〈0.05）.The positive expression of HIF-1a were positively correlated with VEGF and Glut1（rs1=0.681,P〈0.001）（rs2=0.626,P〈0.001）.Conclusion The expression of HIF-1a,VEGF and Glut1 are useful markers for predicting the metastatic potential in gastric carcinoma.Expression of these markers might be useful in the choice treatment.