摘要
目的探讨自拟方补肾活血汤对IgA肾病(IgAN)的疗效及其作用机制。方法经皮肾穿刺活检确诊的IgAN患者57例,A组(20例)用补肾活血汤、B组(20例)用补肾活血汤加贝那普利、C组(17例)用贝那普利治疗;均治疗8周。治疗前及治疗8周后分别检测24-h尿蛋白定量、尿红细胞计数、血肌酐、尿纤维蛋白原降解产物(FDP)及尿N-乙酰β-D氨基葡萄糖苷酶(NAG),并比较治疗前后各指标变化。结果8周后,A、B、C组蛋白尿治疗总有效率分别为75.0%、80.0%和76.5%,A、B组血尿治疗总有效率85.0%和95%,明显高于C组的47.1%(P<0.01);A、B两组尿FDP和尿NAG均明显下降(P<0.01、P<0.05)。结论补肾活血汤对IgAN具有治疗作用,尤其在治疗IgAN血尿方面,疗效明显优于贝那普利。作用机制可能与其降低尿中FDP有关。
Objective To study the therapeutic effect and mechanism of bushenhuoxuetang(BST)in IgA nephritis(IgAN).Methods Fifty-seven patients with IgA nephritis diagnosed by renal biopsy were divided into 3 groups of treated with BST(group A,20 cases),with BST plus benazepril(group B,20 cases)and with benazepril alone(group C,17 cases).The changes of 24-h urinary protein(UP),urinary red cell(URC),serum creatinine(SCr),urinary fibrin degradation products(UFDP),urinary β-N-acetyglocosamidase(UNAG)before treatment and 8 weeks after treatment were observed.Results Eight weeks after treatment,total effective rates for treating UP in groups of A,B and C were 75.0%,80.0% and 76.5%,respectively.Total effective rates for treating hemuresis in groups of A and B were 85.0% and 95%,which were significantly higher than those in group C(P0.01).UFDP and UNAG after treatment were lowered in group A and group B(P0.01 and P0.05).Conclusion BST has therapeutic effects on IgAN,which is better than benazepril in treating IgAN.The possible mechanism is related to a decrease in urinary FDP.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第4期384-386,共3页
Jiangsu Medical Journal
基金
江苏省中医药局科技项目(LB09068)
南通市科技局社会发展基金(S2007033)