血小板和纤维蛋白原在生物材料钛氧膜表面的活化

The activation of platelet(Plt) and fibrinogen(Fig) on biomaterial surface

目的探讨血小板(Plt)和纤维蛋白原(Fig)在新型生物材料钛氧膜(Ti-O)表面的活化。方法测定Ti-O表面Plt黏附量,ELISA法测定表面活化Plt量和构象变化的Fig量,并与热解碳(LTIC)作对照。4只实验犬股动脉内置入Ti-O试片和LTIC试片。结果Ti-O试片对Plt的黏附量、构象变化的Fig量都比对照组低。实验犬股动脉内植入试片1个月后,Ti-O黏附Plt量与形态改变都比LTIC少。结论经过先进技术处理的Ti-O较LTIC有更好的血液相容性。

Objective To study the activation of platelet（Plt）and fibrinogen（Fig）on biomaterial surface.Methods The new biological material（Ti-O）and low temperate isotopic paralytic carbon（LTIC）were placed in the femoral arteries in 4 dogs.The amounts of adhering Plt,activated Plt and Fig transformation on Ti-O surface were measured with ELISA.The low temperate isotopic paralytic carbon（LTIC）was taken as the control.Results The amounts of adhering Plt,activated Plt,and transformation Fig on Ti-O film were less than those on LTIC film.The amounts of adhering Plt and Fig transformation on Ti-O surface were less than those on LTIC film in dogs one month after biomaterial placement.Conclusion The Ti-O film has better heamocompatibility than LTIC.