两种剂量的伐昔洛韦分散片治疗带状疱疹临床疗效对照

The Curative Effect Control of Two Doses Valaciclovir Dispersible Tablets in Treatment of Herpes Zoster

目的比较两种剂量的伐昔洛韦分散片治疗带状疱疹的疗效。方法选择在本院门诊就诊符合诊断标准的带状疱疹患者为研究对象,采用随机、开放、对照的临床试验。治疗组患者采用伐昔洛韦分散片0.15g,2次/d口服,共服10天;对照组患者采用伐昔洛韦分散片0.3g2次/d口服,共服10天。用药后第3,6和10天观察疗效。结果共入组77例,治疗后第3,6和10天,治疗组的有效率分别是32.5%,42.5%,87.5%,对照组的有效率分别是35.1%,62.2%,89.2%,两组患者治疗指数比较差异无统计学意义(P>0.05);疼痛改变(VAS法分值)比较两组间差异无统计学意义(P>0.05)。结论伐昔洛韦分散片治疗带状疱疹0.15g2次/d口服疗效不低于0.3g2次/d口服。

Objective Compare the treatment efficacy of two doses of valaciclovir tablets＇ in treatment of herpes zoster. Methods Herpes zoster in our hospital were selected as the research object by a randomized, open and controlled clinical trials. The treatment group was treated with valaciclovir tablet 0.15g, daily oral 2, serving a total of 10d. The control group was treated with valaciclovir tablet 2 times daily oral 0.3g, serving a total of 10 d. Observe clinical effects on the 3rd, 6th and the 10th days after medication. Results 77 cases were enrolled totally. The effective rates of the treatment group were 32.5% , 42.5% and 87.5% , while the effective rates of the control group were 35.1% , 62.2% and 89.2% after 3, 6 and 10 days＇ treatment. The control group of the therapeutic index in patients with no significant statistical differences （ P 〉 0.05 ） ; compare the ache （Visnal Analogue Scale）, there is no significant statistical differences between the two groups （P 〉0.05）. Conclusion The efficacy of Valacyclovir tablet 0. 15g oral 2 times a day to treat the herpes zoster is not worse than the 2 times daily oral 0.3g.