利妥昔单抗治疗系统性红斑狼疮相关肺动脉高压的前景被引量：2

Rituximab treatment of systemic lupus erythematosus associated pulmonary arterial hypertension:a new insight

下载PDF

导出

摘要肺动脉高压(PAH)是系统性红斑狼疮(SLE)的一种严重并发症,近期研究发现T、B淋巴细胞在PAH的发生过程中发挥重要作用。以B细胞为靶向,而同样对T细胞造成影响的利妥昔单抗(RTX)可能成为治疗SLE相关PAH(SLE-PAH)的有力武器。 Pulmonary arterial hypertension（PAH） is one of the most severe complications of systemic lupus erythematosus（SLE）.Recent studies emphasized the role of T and B lymphocytes in the pathogenesis of PAH.Rituximab（RTX）,not only targeting at B lymphocytes,but also been proven to affect T cells,thus could be a potential treatment for SLE-PAH.

作者王为王迁赵久良李梦涛曾小峰

机构地区中国医学科学院北京协和医学院北京协和医院风湿免疫科

出处《基础医学与临床》 CSCD 北大核心 2010年第3期317-319,共3页 Basic and Clinical Medicine

基金国家"十一五"科技支撑计划(2006BAI01A07和2008BAI59B02) 中华医学会临床医学科研专项资金(08010270105)

关键词利妥昔单抗肺动脉高压系统性红斑狼疮 rituximab pulmonary arterial hypertension systemic lupus erythematosus

分类号 R593.241 [医药卫生—内科学] R543.2 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献10

1Dorfmuller P, Perros F, Balabanian K, et al. Inflammation in pulmonary arterial hypertension [ J ~. Eur Respir J, 2003, 22 : 358 - 363.
2Ulrich S, Taraseviciene-Stewart L, Huber LC,et al. Peripheral blood B lymphocytes derived from patients with idi- opathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study [ J]. Respiratory Research, 2008, 9:20.
3Daley E, Emson C, Guignabert C, et al. Pulmonary arterial remodeling induced by a Th2 immune response [ J ]. J Exp Med, 2008, 205(2):361 -372.
4Allanore Y, Borderie D, Meune C, et al. Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers [J]. Ann Rheum Dis, 2005, 64:481 -483.
5Damas JK, Otterdal K, Yndestad A, et al. Soluble CD40 ligand in pulmonary arterial hypertension: Possible pathogenic role of the interaction between platelets and endothelial cells [ J]. Circulation, 2004, 110:999 - 1005.
6Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, et al. Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling [ J ]. Am J Respir Crit Care Med, 2007, 1175:1280 - 1289.
7Ulrich S, Nicolls MR, Taraseviciene-Stewart L, et al. Increased regulatory and decreased CD8 + cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension [ J]. Respiration, 2008, 75:272- 280.
8Liossis S, Sfikakis PP. Rituximab-induced B cell depletion in autoimmune diseases: Potential effects on T cells [ J ]. Clinical Immunology, 2008, 127:280 - 285.
9Sfikakis PP, Souliotis VL, Fragiadaki KG, et al. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis [ J]. Clinical Immunology, 2007, 123 : 66 - 73.
10Hennigan S, Channick RN, Silverman GJ. Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus., a case report[J]. Lupus, 2008, 17:754 -756.