染色体9p21上两个SNP位点与中国汉族人群心肌梗死的关系

The association of two SNPs on chromosome 9p21 with myocardial infarction in Chinese Hans

目的研究染色体9p21上两个单核苷酸多态性(SNP)位点(rs10757274、rs2383206)在中国汉族人群中的分布,探讨其与心肌梗死(MI)的相关性。方法选择432例初发MI(MI组)及430例外科疾病(对照组)患者,用PCR-SNP Stream技术对rs10757274、rs2383206位点进行SNP分型及分析。结果MI组两个SNP位点的GG、AG基因型分布及G等位基因频率均高于对照组(P均<0.01)。校正混杂因素后显示,两个SNP位点中的G等位基因可使MI患病风险分别提高44%和54%(P<0.01)。结论rs10757274、rs2383206是中国汉族人群MI发生的易感位点。

Objective To investigate the distribution of the SNPs rs10757274 and rs2383206 on chromosome 9p21 in Chinese Hans,and to confirm whether these two loci were associated with myocardial infarction.Methods Four hunderd and thirty-two patients suffered from myocardial infarction and 430 controls were involved for case group and control group,respectively.rs10757274 and rs2383206 were genotyped by PCR-SNP Stream technique.Results The frequency of allele G and genotype GG and AG were increased in MI group when compared with control group（P〈0.01）.After adjusting the confounding factors,we founded the allele G and genotype GG separately increased the risk of MI by 44%,54%（P〈0.01）.Conclusion The SNPs rs10757274 and rs2383206 were susceptible sites to MI in Chinese Hans.