D-二聚体与健康者颈动脉斑块的关系

Relationship between plasama D-dimer and carotid plaque

目的探讨血浆D-二聚体(D-D)与健康者颈动脉斑块的关系。方法以随机整群抽样方法抽取北京市15个社区健康者305例,用ELISA法检测其血浆D-D,并行颈动脉超声检查,根据有无颈动脉斑块分为斑块组98例、无斑块组207例;根据每10岁一个年龄段分5组。结果斑块组血浆D-D高于无斑块组(P<0.01),D-D与颈动脉斑块呈正相关(r=0.235,P<0.01)。65岁以后年龄组颈动脉斑块患病率及Log D-D明显升高。Logistic回归分析,年龄是颈动脉斑块的危险因素,HDL-C是其保护因素。结论血浆D-D是健康者颈动脉斑块的相关因素,有颈动脉斑块的健康者D-D升高可能因增龄所致。

Objective To analyze the relationship between plasama D-dimer and carotid plaque.Methods The healthy ones on the data base of 305 healthy subjects were selected from 15 communities of Beijing.D-dimer was measured by enzyme-linked immunosorbent assay（ELISA）,and carotid artery ultrasound was performed.According to carotid artery plaque,subjects were divided into with-plaque group and without-plaque group（98 cases and 207 cases respectively）.Results D-dimer levels were significantly higher in with-plaque group than that in without-plaque group（P〈0.01）.The D-dimer level correlated significantly with carotid plaque（r=0.235,P〈0.01）.Both the prevalence of carotid artery plaque and Log D-D increased significantly after age of 65 years.Logistic regression analysis revealed that age was a risk factor for carotid plaque,while high-density lipoprotein cholesterol was a protective factor for carotid plaque.Conclusions In healthy adult,plasma D-dimer is associated with carotid plaque,and the incresing of plasma D-dimer level in individul with-carotid plaque could be caused by aging.